Abstract
Pulmonary hypertension (PH) refers to a clinical and pathophysiological syndrome in which pulmonary vascular resistance and pulmonary arterial pressure are increased due to structural or functional changes in pulmonary vasculature caused by a variety of etiologies and different pathogenic mechanisms. It is followed by the development of right heart failure and even death. In recent years, most studies have found that PH and cancer shared a complex common pathological metabolic disturbance, such as the shift from oxidative phosphorylation to glycolysis. During the shifting process, there is an upregulation of glutamine decomposition driven by glutaminase. However, the relationship between PH and glutamine hydrolysis, especially by glutaminase is yet unclear. This review aims to explore the special linking among glutamine hydrolysis, glutaminase and PH, so as to provide theoretical basis for clinical precision treatment in PH.
Highlights
Pulmonary hypertension (PH) is a progressive and vicious vascular disease occurring via multiple mechanisms, which can lead to right heart failure as well as multiorgan dysfunction and is associated with a poor prognosis [1, 2]
Pulmonary hypertension is classified by the World Health Organization (WHO) into five major categories based on the histopathology, hemodynamic characteristics, and possible etiology [6], such as pulmonary arterial hypertension (PAH), PH due to left heart disease, PH due to lung diseases and/or hypoxia, PH due to pulmonary artery obstructions, and PH with unclear
Given the similarities between PH and cancers, the role of glutamine metabolism was explored in the development of pulmonary vascular remodeling
Summary
Shang Wang1†, Yi Yan2,3†, Wei-Jie Xu4†, Su-Gang Gong, Xiu-Jun Zhong, Qin-Yan An6, Ya-Lin Zhao, Jin-Ming Liu, Lan Wang, Ping Yuan1* and Rong Jiang1*. Pulmonary hypertension (PH) refers to a clinical and pathophysiological syndrome in which pulmonary vascular resistance and pulmonary arterial pressure are increased due to structural or functional changes in pulmonary vasculature caused by a variety of etiologies and different pathogenic mechanisms. It is followed by the development of right heart failure and even death. There is an upregulation of glutamine decomposition driven by glutaminase. This review aims to explore the special linking among glutamine hydrolysis, glutaminase and PH, so as to provide theoretical basis for clinical precision treatment in PH
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