The role of genetic determinant in the development of severe perinatal asphyxia

Н Г Горовенко ,S V Podolskaya,Zoia Rossokha ,Валерій Іванович Похилько ,Gunilla A Lundberg

doi:10.3103/s0095452710050063

Abstract

The frequency of GSTT1 and GSTM1 gene deletion polymorphism was determined in a case-control study of full-term Ukrainian newborns including patients with perinatal asphyxia. Multiplex polymerase chain reaction was used for genotyping 245 full-term newborns. The investigated full-term newborns with perinatal asphyxia were subdivided in the subgroups depending of severity of perinatal asphyxia and neonatal outcome. No significant differences in allele frequencies of homorygous null genotypes of GSTT1 and GSTM1 gene were detected among newborns with moderate perinatal asphyxia and healthy control. However, association with the development of severe perinatal asphyxia was detected for the deletion polymorphism in GSTT1 gene and the combination of the GSTT1 absent/GSTM1 absent in the newborns. The study shows that severe perinatal asphyxia may develop in the consequence of genetic predisposition to this condition as compare with moderate.

Highlights

Perinatal asphyxia (PA) is often associated with adverse neurological outcomes including the development of multiorgan injuries and may result in neurological injury with long term disabilities, later disorder with behavioral consequences [1,2,3,4]
Perinatal and maternal risk factors for the PA development were analysed in all investigated groups
No significant difference were found among newborns with PA and healthy controls in the maternal and perinatal risk factors frequencies

Summary

Introduction

Perinatal asphyxia (PA) is often associated with adverse neurological outcomes including the development of multiorgan injuries and may result in neurological injury with long term disabilities, later disorder with behavioral consequences (cerebral palsy, mental retardation, hearing or visual impairment, and attention deficit hyperactivity disorder) [1,2,3,4]. Brain injury in the neonates remains a significant social and health problem, especially with the existence of an unfa vorable neurological prognosis [5]. PA occurs approximately in 4 of 1000 term births and more frequently among preterm delivery neonates. PA is a heterogeneous group with different burden of clinical symptoms with expected adverse out come [3, 6,7,8]

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