Abstract
Background and objectivesIron deficiency anemia (IDA) and the role of genetic variants in determining the iron status in adolescent girls are not yet well-understood. This study aims to investigate the association of the rs602662, rs1049296, rs1805051, rs855791, rs224589, and rs11568350 genes with IDA and iron bio-status parameters.MethodsThis study consisted of 132 patients (IDA group) and 110 healthy controls. The genotype was analyzed through polymerase chain reaction-restriction fragment length polymorphism.ResultsNo differences were noted in the distribution of genotype and allele frequency single nucleotide polymorphism between the IDA and control group. In the IDA group, the GA carriers of rs602662 had a higher hemoglobin concentration (P=0.02) and packed cell volume (P=0.007), whereas transferrin saturation was increased in AA (P=0.02). The genetic variants rs1049296, rs1805051, rs224589, and rs855791 had a non-statistical significance on hematological parameters. Both the GT and TT carriers of the rs11568350 gene showed a low hemoglobin concentration (P=0.02 and <0.001) and mean corpuscular hemoglobin in GT carrier (P=0.01), whereas the TT risk of this gene showed a decreased packed cell volume (P=0.01). In the control patients, no association was observed with serum iron and hematological parameters.ConclusionOf these genetic variants, the GG and GA genotype frequency in rs602662 and the GG, GT, and TT in rs11568350 were associated with low iron status in anemic patients compared to the control patients.
Highlights
Iron deficiency is one of the most important micronutrient deficiencies that affect people worldwide [1-2]
No differences were noted in the distribution of genotype and allele frequency single nucleotide polymorphism between the iron deficiency anemia (IDA) and control group
There are significant gaps in the frequencies of genetic markers of the various populations; various gap-filling tests on the chosen population would make it conceivable to utilize the current perceptions more effectively in developing prophylaxis for a population with high frequencies of IDA, with FPN1 rs11568350 and rs602662 being associated with low iron status in anemic subjects and the predisposition to IDA in adolescent girls
Summary
Iron deficiency is one of the most important micronutrient deficiencies that affect people worldwide [1-2]. When an individual has low iron levels, it may lead to iron deficiency anemia (IDA). The prevalence of IDA among adolescent girls has been reported to be 56% [1], which may be due to inadequate dietary intake and genetic factors [3]. Primary risk factors for IDA among adolescent girls include low dietary iron intake, defective absorption, poor bioavailability, worm infestation, and menstrual blood loss [8]. Genetic variants in iron metabolism have been shown to be associated with IDA [9-10]. The role of genetic factors in iron deficiency in adolescent girls in India is not known. Iron deficiency anemia (IDA) and the role of genetic variants in determining the iron status in adolescent girls are not yet well-understood. This study aims to investigate the association of the rs602662, rs1049296, rs1805051, rs855791, rs224589, and rs11568350 genes with IDA and iron bio-status parameters
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