Abstract
P171 Background: GABA neurotransmission causes membrane hyperpolarization which may counterbalance the toxic effects of glutamate during cerebral ischemia. Although the neuroprotective action of a GABA agonist (Clomethiazole) on acute ischemic stroke is currently being investigated, the importance of GABA in human stroke is unknown. Objective: to analyze whether the concentrations of GABA were related to early stroke outcome in 258 patients with an acute hemispheric cerebral infarction. Methods: GABA was measured using HPLC in blood and CSF samples obtained within 24h from stroke onset, and in blood 48h after admission. Stroke was classified according to Bamford’s scheme. Deterioration was diagnosed if Canadian stroke scale dropped 1 or more points during the first 48h after inclusion. The relative importance of GABA for neurologic worsening was evaluated by logistic regression analysis. Results: GABA concentrations (nmol/L) in plasma and CSF were significantly lower in TACS (108±86 and 44±20) than in PACS (240±164 and 87±60), LACS (377±136 and 134±43), and POCS (374±137 and 134±35) (all p Conclusions: Early neurologic deterioration in acute ischemic stroke is related to low GABA concentrations in blood and CSF, particularly in patients with total or partial anterior circulation syndromes.
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