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Abstract
The role of GABA<sub>A</sub> receptors in the neural systems of the medial preoptic area in the control of GnRH release during the luteal phase of the oestrous cycle in ewes
Highlights
Neuroendocrine control of gonadotropin-releasing hormone (GnRH)/LH release involves both excitatory and inhibitory components
Our previous results strongly suggest that functional interconnection of GABAergic neurons with β-endorphinergic and dopaminergic systems in the ventromedial hypothalamus-nucleus infundibularis (VEN/NI) (TomaszewskaZaremba et al, 2003a) and in the preoptic area (MPOA) (Tomaszewska-Zaremba et al, 2003b) plays an important role in the control of GnRH release during the follicular phase of the oestrous cycle
Since GnRH neuronal activity and function of the β-endorphinergic (Domański et al, 1991; Conover et al, 1993), noradrenergic and dopaminergic (Chomicka et al, 1994) systems in the control of GnRH release depend on gonadal hormone concentrations and changes in various phases of the reproductive cycle, it is reasonable to suggest that the influence of GABA on these systems varies during the time course of the oestrous cycle
Summary
Neuroendocrine control of GnRH/LH release involves both excitatory and inhibitory components. Since GnRH neuronal activity and function of the β-endorphinergic (Domański et al, 1991; Conover et al, 1993), noradrenergic and dopaminergic (Chomicka et al, 1994) systems in the control of GnRH release depend on gonadal hormone concentrations and changes in various phases of the reproductive cycle, it is reasonable to suggest that the influence of GABA on these systems varies during the time course of the oestrous cycle This assumption prompted us to investigate the effect of a GABAA receptor agonist, muscimol, and antagonist, bicuculline, on GnRH and β-endorphin (B-END) release, and on catecholaminergic activity in the MPOA of ewes during the luteal phase of the oestrous cycle
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