The role of G-proteins and G-protein-coupledreceptors in human disease

Abstract

In human diseases associated with G protein, changes in abnormal content and distribution of multiple signalingmolecules and abnormal signaling pathways play critical roles in pathophysiological pathways. Abnormal informationtransmission and signaling pathways are common channels in the pathogenesis of G protein diseases. G protein-coupledreceptors (GPCRs) are the largest group of membrane receptor proteins and represent the most common therapeutictargets for drugs. This paper uses liver injury, blood pressure regulation, Parkinson’s disease, and some cancers toillustrate the pathogenic mechanism and pathway-related treatment of G-protein and GPCR.