Abstract
Background. To evaluate the correlation of fundus autofluorescence (FAF) with indocyanine green angiography (ICGA) in patients with various posterior uveitis disorders. Methods. Interventional case series including 23 eyes of 15 patients with diagnosis of a specific type of retinochoroiditis, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous-like choroiditis, multifocal choroiditis (MFC), Harada disease, and syphilitic retinochoroiditis. Also, some cases with undefined retinochoroiditis were included. FAF and ICGA were performed and correlated at baseline and during follow-up after treatment. Results. In ICGA, early hypofluorescence was found to be the hallmark of acute choroidal inflammation, resolving in later stages and remaining in the late phase in areas with retinal pigment epithelium (RPE) damage. Poorly defined hyperautofluorescent areas correlated with acute choroidal lesions. Hypoautofluorescent delineation suggested the initiation of RPE healing processes, correlating well with the late phase of ICGA and delineating the RPE damage. Early hyperautofluorescence with late hypofluorescence in ICGA indicated the presence of primary RPE involvement. Conclusion. FAF contributes to the interpretation of RPE disease and may be a useful tool for the follow-up of progressive inflammatory disorders. Comparative evaluation of FAF and ICGA allows a characterization of the sequence of inflammatory events and the level of tissue affected.
Highlights
Posterior uveitis is a general classification term, which includes various inflammatory disorders, affecting primarily the retina, the choroid, or both
Specific diagnosis was done based on the results of fundus autofluorescence (FAF), indocyanine green angiography (ICGA), OCT, and fluorescein angiography (FA) imaging in most of cases (Table 1)
There are specific diagnostic tools available in clinical practice, to evaluate the inflammatory disease of the posterior segment of the eye. These tools include standard methods, such as FA and ICGA, OCT, and the novel technology FAF, which is being increasingly utilized as a noninvasive imaging procedure in the field of uveitis
Summary
Posterior uveitis is a general classification term, which includes various inflammatory disorders, affecting primarily the retina, the choroid, or both. Diagnosis and follow-up of posterior uveitis patients have evolved significantly with the advances in imaging technology, such as indocyanine green angiography (ICGA) and fundus autofluorescence (FAF). These imaging tools are complementary to the standard evaluation with fundoscopy and fluorescein angiography (FA) [1, 2]. Inflammation of the choroid and retinal pigment epithelium (RPE) complex often remains occult on thorough fundoscopic examination and FA imaging This is because the initial site of inflammatory. In ICGA, early hypofluorescence was found to be the hallmark of acute choroidal inflammation, resolving in later stages and remaining in the late phase in areas with retinal pigment epithelium (RPE) damage. Comparative evaluation of FAF and ICGA allows a characterization of the sequence of inflammatory events and the level of tissue affected
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