Abstract
To determine if the preovulatory surge of FSH plays a role in the selection of a cohort of follicles destined so ovulate during the subsequent estrous cycle, exogenous FSH was administered on the day before proestrus and the ovaries were examined 24 h later using histological and morphometric techniques. Administration of exogenous FSH I day ahead of she endogenous surge of gonadotropins caused the appearance of a cohort of small pre-Graafian follicles (390-500 pm in diameter) I day ahead of the time of their usual appearance. Elimination of the FSH / LH surge on proestrus. by means of a barbiturate blockade of the surge of gonadotropins. prevented the influx of small pre-Graafian follicles normally seen on estrus. However, replacement of FSH in barbiturate blocked animals restored the appearance of these small pre-Graafian follicles. These results suggest that the FSH surge of one cycle may rescue follicles in the 200-400 pm size range, thereby selecting those follicles which will ovulate during the next cycle.
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