Abstract
A growing body of evidence suggests that pathological features of dementia are diverse and don’t wholly explain variability in dementia incidence. Objective: discuss the role of frailty in dementia expression using evidence from clinical-pathologic cohort studies. Methods: Cross-sectional relationships between neuropathology (Braak, CERAD staging), frailty (frailty index at last study visit before death), and dementia diagnosis at death were performed using data from the Rush Memory and Aging Project (MAP) and the Cambridge City Over 75s Cohort study (CC75C). Results: Participants were 89.7±6.2 and 92.2±4.5 years in MAP (n=451) and CC75C (n=177) and mostly female (69.4-70.1%). Most had dementia (52.8%-59.3%). Frailty was normally distributed (mean FI0.42±0.18 in MAP and 0.34±0.16 in CC75C). Frailty was associated with dementia in MAP (OR=1.88, p<0.001) and CC75C (OR=1.30, p=0.03) after controlling for age, sex, time to death, and neuropathology. Longitudinal analysis is in progress. Frailty appears to play a meaningful role in dementia expression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
