Abstract

The addition of succinylsulfathiazole to highly purified diets containing all dietary factors known to be required by the rat, including pantothenic acid, results in the appearance of signs of severe pantothenic acid deficiency, including achromotrichia and porphyrin-caked whiskers. These changes are accompanied by a marked reduction in the pantothenic acid content of the liver, and are corrected by the inclusion in such diets of crystalline biotin and "folic acid" concentrates. The utilization of pantothenic acid by the rat appears to depend on the availability of biotin and "folic acid." Under normal conditions these are supplied by the diet and synthesized by intestinal bacteria. A hypothesis is offered in explanation of the chromotrichial actions of "folic acid," biotin and p-aminobenzoic acid.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.