Abstract
Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GABAA-receptor resulting in anticonvulsive effects. Objective. This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed. Results/Conclusions. There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy.
Highlights
Epilepsy is one of the oldest recorded neurological disorders, with at least 3000 years of written history [1]
This review provides an overview about the role of flavonoids on oxidative stress in epilepsy and an explanation of the main aspects involved in the development of this pathology
Increased production of free radicals leads to the development of several pathologies like epilepsy, which is among the three most common neurological disorders and involves significant social impact
Summary
Epilepsy is one of the oldest recorded neurological disorders, with at least 3000 years of written history [1] It is the most common neurological condition, affecting 1-2% of the population worldwide and can profoundly affect many aspects of quality of life [2]. Phytomedicines can Oxidative Medicine and Cellular Longevity potentially play an important role in the development of new antiepileptic drugs [10] and may be effective in combating or preventing disease due to their antioxidant effect [11]. This review provides an overview about the role of flavonoids on oxidative stress in epilepsy and an explanation of the main aspects involved in the development of this pathology
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