Abstract
A blinded retrospective validation study was performed in a university-based hospital in northeastern China to determine whether the breast imaging reporting and data system (BI- RADS) defines a group of patients with non- palpable breast lesions (NPBLs) in whom fine- wire localization biopsy (FWLB) is appropriate. We reviewed 182 consecutive patients with NPBLs who underwent FWLB. The patients’ preoperative mammograms were categorized according BI-RADS by 2 radiologists blinded to the pathological findings. The positive predictive values of BI-RADS categories 3-5 were 3.4%, 42.1%, and 76.9%, respectively. For category 4 NPBLs, the percentage of cancer for those aged < 40 years was significantly lower than those aged ≥ 40 years. For category 3 NPBLs, the percentage of precancerous lesions for those aged < 40 years was significantly lower than those aged ≥ 40 years. Chinese NPBL patients aged ≥ 40 years with category 4 mammographic findings, and all patients with category 5 findings should undergo FWLB. FWLB should be offered as a treatment option for Chinese NPBL patients aged < 40 years with category 4 findings or aged ≥ 40 years with category 3 findings.
Highlights
Screening mammography has been shown to reduce breast cancer mortality [1,2,3]
We retrospectively evaluated the mammograms of 182 consecutive women who underwent fine-wire localization breast biopsy (FWLB) of nonpalpable breast lesions (NPBLs) in a tertiary referral cancer center in northeastern China to investigate whether the fourth edition of Breast Imaging Reporting and Data System (BI-RADS) [5] is appropriate for patients in northeastern China with NPBLs and identify the BI-RADS-identified patient subgroups appropriate for FWLB
In adherence to a research protocol approved by the Institutional Review Board and institutional guidelines for ethical human research, we retrospectively reviewed the mammograms, histopathology and medical records of 182 consecutive women with NPBL who underwent FWLB between January 1, 2005 and March 1, 2008 at an affiliated hospital of China Medical University in Liaoning Province of northeastern China
Summary
Traditional mammography has a low positive predictive value (PPV) for breast cancer [4], and many women with benign breast lesions undergo open surgical biopsy. In this context, the Breast Imaging Reporting and Data System (BI-RADS) classification scheme was developed by the American College of Radiology to improve mammographic reporting through the use of standardized descriptive terms [5]. BI-RADS offers specific PPV for each category of mammographic lesions and is useful for discriminating many benign from malignant lesions and for potentially reducing the number of unnecessary open breast biopsies performed. We retrospectively evaluated the mammograms of 182 consecutive women who underwent fine-wire localization breast biopsy (FWLB) of NPBLs in a tertiary referral cancer center in northeastern China to investigate whether the fourth edition of BI-RADS [5] is appropriate for patients in northeastern China with NPBLs and identify the BI-RADS-identified patient subgroups appropriate for FWLB
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
