Abstract
The functional role of soluble fibrin monomer (FM) complexes in vivo is not known and the clinical significance of its laboratory measurement unclear. The effect of FM on the development of experimental venous thrombosis was evaluated. Laboratory determination of FM by ethanol gelation and protamine sulfate paracoagulation in the presence of serum‐induced thrombosis was performed. FM in vivo was formed by the administration of thrombin and by the infusion of soluble fibrin. FM was found not to significantly potentiate thrombus formation in this experimental model. Furthermore, extensive thrombosis occurred without demonstrable circulating FM. The results suggest that the presence of FM in the blood is not a reliable measure of incipient venous thrombosis. The laboratory demonstration of FM in association with deep vein thrombosis probably reflects the result and not the cause of the thrombus. During this study, a potent anticoagulant and antithrombotic activity induced by thrombin in vivo was demonstrated. Some of the experimental results were related to this activity. Preliminary studies of this activity are presented and its pathophysiologic significance considered.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
