Abstract

The role of <scp>FGF</scp>2 in spinal cord trauma and regeneration research

Highlights

  • We read with interest the article by Goldshmit et al in this issue of Brain and Behavior

  • Crucial to why central nervous system (CNS) does not repair itself compared to the peripheral nervous system (PNS) is the difference in the inherent abilities of the glial cells in these systems

  • Research has shown that the injured neurons initiate neurite outgrowth both in the CNS and PNS

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Summary

Introduction

Research has shown that the injured neurons initiate neurite outgrowth both in the CNS and PNS. Most important are the neurite inhibitory effect of the exposed Nogo’s on the surface of the injured oligodendrocytes, the relative lack of enhanced growth factor production by injured glia in the injured area, and the cavitation and the scar tissue formation induced by the inflammatory reaction (Steward et al 1999; Norenberg et al 2004; Profyris et al 2004).

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