Abstract
The role of <scp>FGF</scp>2 in spinal cord trauma and regeneration research
Highlights
We read with interest the article by Goldshmit et al in this issue of Brain and Behavior
Crucial to why central nervous system (CNS) does not repair itself compared to the peripheral nervous system (PNS) is the difference in the inherent abilities of the glial cells in these systems
Research has shown that the injured neurons initiate neurite outgrowth both in the CNS and PNS
Summary
Research has shown that the injured neurons initiate neurite outgrowth both in the CNS and PNS. Most important are the neurite inhibitory effect of the exposed Nogo’s on the surface of the injured oligodendrocytes, the relative lack of enhanced growth factor production by injured glia in the injured area, and the cavitation and the scar tissue formation induced by the inflammatory reaction (Steward et al 1999; Norenberg et al 2004; Profyris et al 2004).
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