Abstract
Studies with animal models for mammary tumorigenesis have demonstrated that high levels of dietary fat influences the development of mammary tumors. In the mouse model mammary tumor development is initiated either by expression of preexisting mammary tumor virus (MTV) or by exposure to chemical carcinogens. While high levels of polyunsaturated omega-6 fatty acids are known to enhance spontaneous mammary tumor development, saturated fatty acids are inhibitory to tumor development in mice (1–3). Fatty acid-induced modulation has also been observed in transplantable mammary carcinomas in mice (4–6). Because of distinct strain-dependent differences in tumorigenesis in mice that are usually accompanied by a specific preneoplastic morphologic atypia, the effects of dietary modulators on mammary cell proliferation, differentiation and tumorigenic transformation have been extensively investigated.
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