Abstract
The role of exosomes in diagnosis of non-haematological malignancies
Highlights
Cancer has remained a significant public health problem worldwide
The present work was carried out to decipher the exact status of exosomes as a liquid biopsy tool in non-haematological malignancies
Keeping with the rapid strides made in our understanding of tumor biology, a slow but definite shift in cancer management protocols has taken shape
Summary
Cancer has remained a significant public health problem worldwide. While early diagnosis and increased awareness have improved cancer survival, there remained a need to identify less invasive biomarkers which could prove effective in early diagnosis, aid prognostication and guide therapeutic decision making. A vast body of literature on the role of nano-sized particles like exosomes in various malignancies was available [1], their current status in personalized cancer medicine was still unclear. Ultracentrifugation and size based techniques have been employed for isolation of exosomes [26]. These techniques got limited owing to their high costs, being labor intensive and/or having low specificity. While the detection of exosomal contents like EpCAM and CD24 offered an opportunity for early diagnosis of ovarian malignancies, CD24 has even proved to be a useful prognostic marker [40,41]. The conundrum regarding tumor heterogeneity and various complex host-tumor interactions on the exosomal yields needs to be solved [70]
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