The role of exogenous adenosine triphosphate administration for the prevention of ischemia-reperfusion injury in skeletal muscle

Abstract

Organ preservation solutions are essential for the temporary storage of tissue prior to transplantation or reimplantation. The depletion of oxygen stores occurs within a few seconds. Stored energy in the form of creatine phosphate (CP) and adenosine triphosphate (ATP) is depleted. Anaerobic glycolysis then occurs followed by an attempt to maintain normal cellular function. However, glycolysis cannot maintain tissue survival for long. Metabolic waste accumulates and the cellular pH decreases. Mitochondrial ATP generation is blocked because of a lack of molecular oxygen, and insufficient supply of NAD+ also causes the Krebs cycle to cease function.