Abstract
There is a growing appreciation of the role of ovarian hormones as modulators of neuronal function within the central nervous system (CNS). Ovarian failure has long been known to result in reversible changes in mental function, affect, and behavior. More recent epidemiological investigations demonstrate that ovarian failure may result in changes in mental function that can be characterized by an acceleration of brain aging. The clinical expression of these changes are injurious falls, hip fracture, and automobile accidents which can be attributed to a slowing of brain processing of complex sensory information and the generation of a timely response. Estrogen deficiency is also associated with the earlier expression of Alzheimer’s disease. These effects of estrogen can be attributed to the multiple mechanisms whereby estrogens modify brain and neuronal function.
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