Abstract

Abstract—Using Raman spectroscopy, atomic force microscopy, and laser interferometry we found that variations in insulin-like growth factor (IGF-1) and purinergic compounds such as ATP in the blood influence the hemoglobin distribution and hematoporhyrin conformation in hemoglobin in erythrocytes. Our results suggest that receptor activation promotes changes in conformation of cytoskeletal protein molecules and hemoglobin.

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