The Role of Endothelial Dysfunction in the Development of Cardiotoxic Action of Cytostatics in Patients with Lymphoproliferative Diseases

Abstract

Understanding mechanisms of chemotherapy cardiotoxicity is an important problem due to the lack of clear understanding of its occurrence.Development of endothelial dysfunction is considered to be one of possible ways in implementation of these side effects. The analysis of endothelin-1 and e-selectin levels in 26 patients with lymphoproliferative diseases before and after the completion of the treatment program was beenperformed. The results of the study showed normal values of E-selectin level and increased level of endothelin-1 in the whole group of patientsbefore treatment. After completion of chemotherapy program, in the whole group, there was a decrease of these two markers. However, valuesof level of endothelin-1 with vasoconstrictor effect remained high even after the end of therapy. It is imp ortant that at detailed analysis the dynamicsof investigated markers in patients of older age group (median age 64 years) was associated with worsening of endothelial dysfunction.