Abstract

Gallbladder (GB) diseases represent various lesions including gallstones, cholesterol polyps, adenomyomatosis, and GB carcinoma. This review aims to summarize the role of endoscopic ultrasound (EUS) in the diagnosis of GB lesions. EUS provides high-resolution images that can improve the diagnosis of GB polypoid lesions, GB wall thickness, and GB carcinoma staging. Contrast-enhancing agents may be useful for the differential diagnosis of GB lesions, but the evidence of their effectiveness is still limited. Thus, further studies are required in this area to establish its usefulness. EUS combined with fine-needle aspiration has played an increasing role in providing a histological diagnosis of GB tumors in addition to GB wall thickness.

Highlights

  • Mitsuo Nagasaka, Department of Gastroenterology and Hepatology, School of Medicine, Fujita Health University, Citation: Hashimoto, S.; Nakaoka, K.; Kawabe, N.; Kuzuya, T.; Funasaka, K.; Nagasaka, M.; Nakagawa, Y.; Abstract: Gallbladder (GB) diseases represent various lesions including gallstones, cholesterol polyps, adenomyomatosis, and GB carcinoma

  • The role of endoscopic ultrasound (EUS) in the diagnosis of GB lesions has been demonstrated in many studies, and this review aims to summarize the role of EUS in the diagnosis of GB pathologies

  • The current study found no studies for the detection of gallbladder polypoid lesions on EUS

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Summary

Literature Research

We conducted our literature research in the PubMed and Scopus electronic databases using combinations of the following key words: endoscopic ultrasound, gallbladder diseases, gallbladder neoplasm, and gallbladder carcinoma/cancer. We narrowed the research timeline to the period from 1991 to 2021. After initial selection based on exclusion criteria such as languages other than English, lack of access to a paper, and after having removed duplicates, we reviewed papers for further evaluation. From these papers, we mainly referred to our own papers and adopted 65 papers for this review. This review is written in the style of narrative review

EUS Compared with Transabdominal Ultrasound to Detect GB Lesions
Differential Diagnosis of GB Lesions
Differential Diagnosis of GB Protuberant Lesions
EUS image
Differential Diagnosis of GB Wall-Thickening Lesions
GB Carcinoma
Contrast-Enhanced EUS
Study Design
EUS of image
EUS-FNA for GB Lesions
Findings
Conclusions
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