Abstract
s / International Journal of Surgery 11 (2013) 589e685 623 ABSTRACTS Aims: This study aims to establish the risk factors present in a cohort of patients with grade 3 anal intraepithelial neoplasia (AIN3) and the rate of progression to anal squamous cell carcinoma (SCC). Methods: Patients with a histological diagnosis of AIN3 in Cardiff and Vale NHS trust between 2007 and 2012 were reviewed. Results:26patientswere identifiedwithamean followupof3years.11 (42%) presented with SCC on a background of AIN3, 15 (58%) with AIN3. 73% of patients were current or ex smokers. Of patients presenting with AIN3, 7 (47%) reported previous anogenital warts and 3 (20%) were HIV positive. 6 women (35%) had concurrent genital intraepithelial neoplasia (4 cervical, 1 vulval, 1 vaginal). 1 patient (4%) was immunosuppressed after a renal-allograft.10patientsunderwent chemo-radiotherapy for SCC,withno recurrence of AIN3whilst 1 died ofmetastatic disease. 60% of AIN3patientswere disease freeat the timeof thestudyafter local excision.The rateofprogressionofAIN3 to SCC was 20% despite on-going surveillance and treatment. Conclusion: The cohort demonstrated known risk factors for AIN3 and showed a rate of progression to SCC higher than previously reported. 0588: FACTORS PREDICTIVE OF WOUND INFECTION IN A COLORECTAL UNIT. A CASE-CONTROL STUDY Catherine Power, Mike Davies, Rachel Hargest, Simon Phillips, Chris Morris. Department of Colorectal Surgery, University Hospital of Wales,
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
