Abstract
The role of endocrine disruptors in the present and future human endocrine evolution: The ed-exohormone-system
Highlights
BackgroundThe human evolution has not stopped [1] and new kind of factors are shaping it
The ubiquitousness of endocrine disruptors (EDs) is characteristic to our present age, despite the fact that EDs were present in the human environment earlier, and could possibly had an evolutionary role.The substances called lipid-soluble vitamins, such as vitamins A, D, E and K could have been such EDs in earlier times
The Asian population consumes soy foods' for thousands of years, the effect of this hormonal provocation - in contrast to the phytoestrogen-less European populations - was not thoroughly recorded.This period of time had to be enough for the infiltration of this EDs into the human organism, to the infiltration of lipid-soluble vitamins to the whole human population, which consumes carrots, milk, egg, fish or mushroom etc. for supplementing vitamin A and D
Summary
The human evolution has not stopped [1] and new kind of factors are shaping it. Some of these factors originate from human activity itself and they are often followed by a backlash manifested in evolutionary alterations. The ubiquitousness of EDs is characteristic to our present age, despite the fact that EDs were present in the human environment earlier, and could possibly had an evolutionary role.The substances called lipid-soluble vitamins, such as vitamins A, D, E and K (which hormones, as they are bound by hormone receptors, inducing response) could have been such EDs in earlier times. Csaba G (2019) The role of endocrine disruptors in the present and future human endocrine evolution: The ed-exohormone-system the organism, a special receptor could have developed and fixed for binding the vitamin (retinoid receptor), having a hormonal effect. It seems likely that the other two lipid soluble vitamins, vitamin E and K [10,11,12] had a similar route during the transformation from endocrine disruptors to outer (exo)- hormones These vitamin-hormones are bound presently by the pregnane-X receptors and the specific prospective receptor (likely) develops later. In principle it can be imagined that during a relatively short time such new outer (exo) -hormones will appear which have ED-hormonal origin
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