Abstract
In the past decade great efforts have been devoted to the development of better methodology for enantioselective chromatography, and they have resulted in new chiral stationary phases, pioneered by Pirkle and Pochapsky. It has been shown that chromatographic parameters obtained by chiral stationary phases can be sensitive to very subtle differences between the enantiomers. One of the most appealing types of chiral stationary phases for pharmaceutical analysis involves the use of protein immobilized on the surface of silica gel or other support as the chiral discriminator. The mechanism of chiral discrimination by the various chiral stationary phases described here becoming more apparent. It was interesting to note, during a literature search of works describing the application of chiral separations in the pharmaceutical sciences, that publications describing the use of chiral stationary phases since 1986 unnumbered all the earlier publications involving direct analysis of enantiomers by CSPs.
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