Abstract
F-box protein is a substrate recognition subunit of SCF (SKP1-cullin-F-box) E3 ubiquitin ligase. It participates in the ubiquitination and degradation of various proteins in ubiquitin proteasome pathway (UPP). F-box protein regulates the occurrence of epithelial mesenchymal transition (EMT), which is achieved by regulating the EMT-related inducer. EMT can promote the invasion and metastasis of tumor cells. Thus, the involvement of F-box protein in the degradation of protein is closely related to the invasion and metastasis of tumors. Therefore, the research and development of drugs against F-box protein can provide a basis for clinical control of tumor invasion and metastasis. This article mainly reviews the characteristics of the F-box protein and its mechanism of action in the regulation of EMT so as to clarify the role of F-box protein in tumor invasion and metastasis. Key words: EMT; Transcription factor; F-box; The ubiquitin-proteasome system
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