Abstract
eIF-4C has a pronounced stimulatory effect on initiation complex formation with native 80-S ribosomes (80-S n) as the only source of ribosomal subunits, but only a small effect when washed 40-S subunits are used. eIF-4C is accessary to eIF-3 in dissociating 80-S n ribosomes. eIF-4C is present on 40-S n but absent on 40-S n dimers, which occur in preparations of native ribosomes and are as such inactive in protein synthesis. eIF-4C dissociates 40-S n dimers into active monomers. These results can be explained by assuming that the presence of eIF-4C on 40-S n prevents: 1. (a) premature association with 60-S ribosomal subunits and 2. (b) dimerisation, thus increasing the rate and extent of initiation complex formation.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
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