Abstract
Background:TheRelativeAtrial Index (RAI) is a reliable indicator of intracardiac shunting. The suggested normal cut-off value is RAI 1.0 highly predictive of atrial septal defects (ASDs). This study tests this cut-off in patients with secundum ASDs undergoing percutaneous closure. Results: Sixty-one patients with ASDs (mean age, 49 years± 17; 34 women) underwent transthoracic echocardiography (TTE) prior to Amplatzer percutaneous ASD closure. Following closure, patients underwent sequential TTEs at day 1 post-closure (n= 53); at follow up (n= 54); or at both (n= 46). The RAI prior to closure was 1.15± 0.27 with 72% of patients correctly classified as having ASDs (true positives). At day 1, the RAI fell significantly to 0.98± 0.22 (p< 0.01). At follow up (mean 199 days, range 14–1055 days), the RAI fell further to 0.81± 0.14 (p< 0.001), 475
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