Abstract
Hyperlipidemia is a known cause of atherosclerosis and directly contributes to the current epidemic in cardio-vascular disease. Pregnancy is typified by an increase in serum levels of total cholesterol and triglycerides pushed by the rise in estrogen, progesterone and lactogen. Mobilization of stored fat depots in late pregnancy may provide a reservoir of fatty acids for fetal growth and placental tissue steroid synthesis. This physiologic increase in lipids performs an essential role during pregnancy. However, elevated levels of lipids in predisposed women can carry increased risk for maternal-fetal complications. Hyperlipidemia during pregnancy is associated with preeclampsia, preterm birth and gestational diabetes. Lipid profile abnormalities in maternal patients with GDM increase the risk of vascular injury, which may lead to endothelial dysfunction. Offspring of these mothers show a propensity to enhanced fatty streak formation and an increased risk of progressive atherosclerosis, neurological, cognitive and emotional disorders
Highlights
Hyperlipidemia is a known cause of atherosclerosis
Pregnancy is typified by an increase in serum levels
of total cholesterol and triglycerides pushed by the rise in estrogen
Summary
Olmos et al [29] уверены, что у младенцев, рожденных у матерей с ожирением и ГСД, даже при нормогликемии, повышается риск развития макросомии, обусловленный ростом уровня триглицеридов в материнской крови. Su et al [53] доказали, что экспрессия IGF2 в пуповинной крови и плаценте была достоверно выше в группе беременных с ГСД и макросомией по сравнению с женщинами, имеющими нормальную толерантность к глюкозе и нормальный вес ребенка при рождении.
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