Abstract
Protein - protein interactions regulate and control a wide range of physiological processes. Protein interaction networks abound with proteins that have only a few connections while a small number of proteins, which are called hub proteins, are highly connected. Recent reports suggest that hub proteins are structurally and dynamically different from non-hub proteins. Hub proteins tend to be more disordered than other proteins. Further, binding partners of hub proteins are also observed to have higher levels of disorder. Here we perform a detailed examination of hub and non-hub proteins using the Gaussian Network Model (GNM) to elucidate the role of intrinsic dynamics for binding diversity and promiscuity.
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