The role of dual time point FDG PET imaging in the evaluation of solitary pulmonary nodules with an initial standard uptake value less than 2.5

Abstract

To evaluate the accuracy of dual time point 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) imaging in the evaluation of the mildly metabolic solitary pulmonary nodule (SPN) and to assess whether accuracy could be improved by delaying second image acquisition to 180 minutes. Fifty-four patients were included in the study. Thirty-six had an SUV(max) <2.5 at 60 min. For these patients, two methods of interpreting the subsequent delayed FDG PET imaging at 180 min were investigated. The first method analysed the SUV(max) of SPNs on delayed imaging, in which an SUV(max) of 2.5 or more was regarded as a criterion for malignancy. The second method was retention index (RI) analysis, in which an increase of 10% or more in SUV(max) between the initial and delayed images, was regarded as an indication of malignancy. For the group as a whole (n=54), the sensitivity, specificity and accuracy of using an SUV(max) of 2.5 or more as an indication of malignancy at the time of initial image acquisition (60 min) was 58, 89, and 74%, respectively. For SPNs that had an initial SUV(max) <2.5 (n=36), the sensitivity, specificity, and accuracy of using an SUV(max) of 2.5 or more as a criterion for malignancy on the delayed image acquisition (180 min), was 36, 96, and 78% respectively. However, if an RI of >10% was used as a criterion for malignancy between the initial and delayed images, the sensitivity, specificity, and accuracy was 73, 80, and 78%, respectively. These results are similar to a recent paper, where image acquisition occurred at 60 and 120 min post-tracer injection. Dual time point FDG PET imaging with RI analysis, is a useful technique in evaluating SPN with an initial SUV(max) <2.5. Prolonging second image acquisition from 120 to 180 min does not appear to improve the accuracy of this technique. However, given that maximal FDG uptake by lung carcinomas is thought to be in the region of 5h, it may be that improving the accuracy of dual time point FDG PET imaging requires a more significant delay in second image acquisition in this specific subgroup.