The role of distinct interneuron cell types in initiation and maintenance of persistent activity in a prefrontal cortical microcircuit model

Abstract

Event Abstract Back to Event The role of distinct interneuron cell types in initiation and maintenance of persistent activity in a prefrontal cortical microcircuit model Xanthippi Konstantoudaki1*, Kyriaki Sidiropoulou1, Athanasia Papoutsi1 and Panayiota Poirazi1 1 FORTH-IMBB, Greece Neurons in the prefrontal cortex (PFC) exhibit sustained firing following a stimulus, an activity pattern that underlies the on-line maintenance of a memory. Both pyramidal neurons and inhibitory interneurons exhibit stimulus-selective sustained activity. The interneurons comprise the most numerous and diverse cells in the cortex, although the role for such diversity remains elusive. Our goal is to identify the role of different types of interneurons in shaping the emergence and maintenance of persistent activity in a PFC model microcircuit. Towards that goal, we have used the NEURON simulation environment to model the three different types of interneurons present in PFC, identified by the calcium-binding proteins expressed, parvalbumin (PV), calbidin (CB) and calretinin (CR). All three interneuron models consisted of one compartment and included the ionic mechanisms for the fast sodium, fast potassium and delayed-rectifier potassium currents as well as other ionic mechanisms that differentiate each type, based on experimental studies. The PV model included mechanisms for the slow potassium current, one type of high-threshold activated calcium current (N-type, ICaN), and the hyperpolarization-activated potassium current (H-current, Ih) and exhibited very high frequencies upon activation. The CB model included mechanisms for the low-threshold calcium current (T-type) and Ih, and had a low threshold of activation. The CR model included mechanisms for the slow potassium current, a fast calcium-activated potassium current and the ICaN and displayed irregular firing behavior. All three different interneuron models were validated against experimental data to ensure their proper physiological behavior. These three different interneuron models will be included in a microcircuit that includes four pyramidal neuron models in order to study how they affect the emergence and maintenance of the persistent activity induced by the microcircuit. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Konstantoudaki X, Sidiropoulou K, Papoutsi A and Poirazi P (2009). The role of distinct interneuron cell types in initiation and maintenance of persistent activity in a prefrontal cortical microcircuit model. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.198 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Jun 2009; Published Online: 10 Jun 2009. * Correspondence: Xanthippi Konstantoudaki, FORTH-IMBB, Crete, Greece, xeniakons@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Xanthippi Konstantoudaki Kyriaki Sidiropoulou Athanasia Papoutsi Panayiota Poirazi Google Xanthippi Konstantoudaki Kyriaki Sidiropoulou Athanasia Papoutsi Panayiota Poirazi Google Scholar Xanthippi Konstantoudaki Kyriaki Sidiropoulou Athanasia Papoutsi Panayiota Poirazi PubMed Xanthippi Konstantoudaki Kyriaki Sidiropoulou Athanasia Papoutsi Panayiota Poirazi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.