Abstract
Akinesia is the mostdisabling symptom of Parkinson's disease. The neuralmechanisms underlying itprobably involve the descending projections of the basalganglia to the brain stem as itimproves after a pallidotomy or subthalamic nucleotomy but not after a thalamotomy. We describe the effects of lesioning the pedunculopontine nucleus in the normal primate in generating an akinetic syndrome. The possible clinical implications of this study are discussed.
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