Abstract
The role of deoxycorticosterone (DOC) in the pathogenesis of adrenal regeneration hypertension (ARH) was investigated. DOC concentration in the peripheral plasma of rats was measured by a competitive protein binding method at intervals of 1 day to 7 weeks after adrenal enucleation. Immediately after adrenal enucleation plasma DOC dropped to near unmeasurable levels but as adrenal regeneration occurred it rose rapidly to a peak at 3 weeks, approximately 6 times that of controls. The plasma concentrations attained were shown to be sufficient to account for the observed concomitant hypertension. After 3 weeks plasma levels of DOC declined gradually and reached normal levels at 7 weeks but the hypertension progressed. Hence, while DOC alone can probably account for the initiation of ARH, other factors may be involved in its maintenance. (Endocrinology91: 921, 1972)
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