The Role of Daruharidra as Pramehaghna Karma with Special Reference to Madhumeha

Abstract

There are many drugs described in Ayurveda which can be used in the treatment of ,Madhumeha. Sometime different species of that particular drug is sold in market having no therapeutic use or having no record of therapeutic potential under same vernacular name. In this study the drug Daruharidra has been selected. The exact botanical source of Daruharidra is root of Berberis aristata D.C, but more than 13 species of berberis are available throughout Himalayan region ranging from 3,000-13,000ft height. One of it is Berberis asiatica, which is considered as a substitute of B.aristata but no such scientific work has been done to prove it. Secondly now days due to ban in uprooting of Daruharidra, physician has started using stem. So, in this studystem ofboth species is assessed for its efficacy in Prameha. In Berberis aristata D.C group 14 patients completed the drug regime, highly significant (P<0.001 relief was seen in Prabhutamutratrata(83.47%), Kar-pad-tal dah(86.40%) and Daurbalyata(62.50%) and postprandial blood sugar was significantly reduced (P<0.05). In this group 14.28% patient markedly improved, 57.14% patients improved and 28.57% patients were in unchanged category. In B.asiatica group 14 patients completed the drug schedule, highly significant(P<0.001) relief was observed in prabhutamutrata (59.02%) and Kar-pad-tal dah(62.71%) and post-prandial blood sugar level was significantly reduced (P<0.05).As overall effect of drug is concern 07.14% patients controlled,14.28% patients markedly improved,57.14% improved, and 21.42% in unchanged category. No difference was observed in the therapeutical potential of Berberis aristata D.C. and Berberis asiaticaRoxb.ex.D.C clinically. As in pharmacological and Clinical study not much difference is observed in both the drugs, but the water soluble extractive and Berberine quantity is higher in B.asiatica groups so B.asiatica can be used in preparation of Rasanjan and other products.