Abstract
Acute stress reduces and adaptation to stress enhances thermal resistance of Ca2+ pump of the sarcoplasmic reticulum fraction. Soluble cytoplasmic factors increase the rate of Ca2+ transport into myocardial sarcoplasmic reticulum and its thermal resistance in the stressed, stress-adapted, and control rats, the activating effect being most pronounced during acute stress. Structural and functional mechanisms underlying the protective effect of soluble cytoplasmic factors on membrane-bound enzymes are discussed.
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