The Role of Cytokines and Adhesion Molecules in Lung Inflammation

Abstract

The roles of cytokines in the development of inflammatory reactions and subsequent tissue injury have been the topic of many different studies. In the context of the acute inflammatory reaction triggered by intrapulmonary deposition of IgG immune complexes, it is now clear that cytokine elaboration is necessary for the full development of the inflammatory reaction which leads to acute damage of vascular endothelial cells and alveolar lining epithelial cells. In contrast, lung injury that follows deposition of IgA immune complexes is neither associated with elaboration of cytokines nor is it related to a requirement for cytokines. In this report we will examine our current understanding of the events leading to acute pulmonary injury following deposition of IgG or IgA immune complexes. The findings underscore the different requirements for cytokines and the implications for these differences.