Abstract
Steroid hormones from adrenal glands are synthesized from cholesterol via several monooxygenase reactions catalysed by different species of cytochrome P-450. P-450 scc and P-450 11β are located in the mitochondria and P-450 c21 and P-450 17α,lyase are located in the endoplasmic reticulum. There are different electron transfer pathways from NADPH to cytochrome P-450 in the two organelles. The metabolic intermediates move back and forth between the organelles during the synthetic process. Recently, steroidogenic electron transfer systems have been reconstituted and well characterized.
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