Abstract
Department of Physiology and Biochemistry, University of Southampton, Southampton, S09 3TU and *Department of Physiology and Pharmacology, INSERM U7, Hopital Necker, 75015 Paris, France (Revised manuscript received 21 January 1976) Angiotensin has a number of actions which include stimulation of sodium transport by rat colon and kidney (Parsons & Munday, 1972). Attempts to implicate cyclic AMP as a mediator of angiotensin responses have proven inconclusive. Kaplan (1965), Davies, Munday & Parsons (1972) and Munday, Parsons & Poat (1972) were unable to mimic angiotensin responses with cyclic AMP derivatives or theophylline, whereas Coviello (1973) and Hornych, Meyer & Milliez (1973) obtained angiotensin-like effects following the application of cyclic AMP. The possible involvement of cyclic AMP in the responses of intestine and kidney has been re-assessed using direct measurements of adenyl cyclase activities and tissue cyclic AMP concentrations in two independent laboratories. Fluid and sodium transport was measured in stripped sacs of
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