Abstract
CXCR4 and CXCL12 signaling pathway is important for stem cell homing in myocardial ischemia and cardiovascular regeneration. Recently report shows that CXCR4 and CXCL12 signaling pathway is involved in coronary collateral growth in myocardial ischemia. Endothelial cells are a key players in the coronary collateral growth. In this study, we use genetically modified mice CXCR4 endothelial cell specific knockout mice to study the role of CXCR4 in endothelial cells in myocardial ischemia. First, we study the role of CXCR4 in endothelial cells in coronary collateral growth in our mouse model by inducing repetitive ischemia. Second, we use the mouse myocardial infarction model to study the role of CXCR4 in endothelial cells in cardiovascular regeneration. We measure the cardiac function, vessel density and coronary blood flow in the the heart. Our preliminary data showed that the deletion of CXCR4 changes cardiac function and coronary collateral growth and the CXCR4 and CXCL12 signaling pathway is essential to cardiovascular regeneration. It suggested that CXCR4/CXCL12 signaling pathway as a potential target for the development of therapeutic treatment for coronary artery diseases and prevention of heart attack.
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