Abstract
Vitiligo is a depigmenting disease caused by the loss of melanocytes owing to autoimmune cytotoxic activity and, as was recently described, basal melanocyte detachment (Boukhedouni et al., 2020). IFN-γ plays an important role in CXCL10 secretion and participates in TCD8+ cell recruitment to the affected skin through its receptor, CXCR3 (Wang et al., 2016). CXCL10 is significantly elevated in more severe vitiligo (Abdallah et al., 2018; Zhang et al., 2020) and is important in the maintenance of the depigmented phenotype in a mouse model of vitiligo (Rashighi et al., 2014).
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