Abstract
Adult male Fundulus heteroclitus were found to respond to a number of nonspecific stress stimuli with transient elevations in serum cortisol levels. Metyrapone treatment suppressed stress-stimulated peaks but did not alter resting cortisol levels. Metyrapone elevated serum “11-deoxycortisol” levels. In a 30-hr stress experiment, fasted fish exposed to restraint stress exhibited marked hyperglycemia. Metyrapone-treated fish exposed to the same stress responded with an initial hyperglycemia but did not exhibit the sustained peak seen in untreated fish. Liver glycogen concentrations in stressed fish were somewhat higher than in metyrapone-treated, stressed fish. No significant changes occurred in muscle glycogen, serum protein, or amino acid content of serum, liver, or muscle in stressed fish. Cortisol appears to function during stress in this species to sustain the elevation in serum glucose.
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