Abstract
Gap junctions (GJ) are the most important cell-to-cell structures; that plays the role of intercellular communication and maintenance of cellular homeostasis in epithelium, muscle and neural tissues and also in more tissues and organs. These communication domains and also their composer proteins are called and they show a wide range in all of the mammalian cells. Six connexin monomers join together and form a hemichannel called connexon. The different types of connexons bind the cell to an adjacent connexon and make the cell ready for gap junctional intercellular communication (GJIC). In last years, recent data of concerned experiements show that the structural precursors of gap junctions; connexins and in attendance connexons or hemichannels, can affect the cellular homeostatic balance independently of gap junctional intercellular communication (GJIC). In this review, the role of connexins and their channels with connexin diversity mentioned and also the cell cycle of them are discussed.
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