Abstract
This study aimed to investigate the off-label use of a combination calcipotriol plus betamethasone dipropionate (CBD) gel in the treatment of moderate-to-severe scalp seborrhoeic dermatitis (SSD). This retrospective study involved 32 patients with SSD who were prescribed CBD gel at the Subang Jaya Medical Centre, Selangor, Malaysia, between January 2016 and December 2017. The Physician Global Assessment Scale was used to assess disease severity. Itching/discomfort was evaluated using a visual analogue scale. The mean age was 35.8 ± 6.9 years. Severe disease was seen in 53.1%. Complete clearance was recorded in 15.6%, 40.6% and 59.4% of patients at weeks two, six and 10, respectively. By week 10, 87.5% had achieved marked improvement. Both mean itching and discomfort scores significantly improved at weeks two, six and 10 (P <0.001). Better outcomes were significantly associated with disease duration and itching intensity and discomfort at presentation (P <0.050). CBD gel should be considered as an option for SSD cases not adequately controlled by prior conventional treatment.
Highlights
Objectives: This study aimed to investigate the off-label use of a combination calcipotriol plus betamethasone dipropionate (CBD) gel in the treatment of moderate-to-severe scalp seborrhoeic dermatitis (SSD)
Based on the assumption that both scalp psoriasis and seborrhoeic dermatitis have an inflammatory component in the disease process, the use of a CBD gel might be beneficial in treatment of the latter condition.[7]
In a randomised controlled trial, Kragballe et al observed that use of a CBD gel in scalp psoriasis allowed for both rapid clearance and a longer remission period.[6]
Summary
Abstract: Objectives: This study aimed to investigate the off-label use of a combination calcipotriol plus betamethasone dipropionate (CBD) gel in the treatment of moderate-to-severe scalp seborrhoeic dermatitis (SSD). One example is a combination of calcipotriol plus betamethasone dipropionate (CBD), an effective topical agent for the treatment of scalp psoriasis in which complete clearance can be seen as early as two weeks.[5,6]. Conventional treatments for seborrhoeic dermatitis are based on the presumed pathogenesis and proliferation of Malassezia furfur and the patient’s heightened immunological response.[2] Based on the assumption that both scalp psoriasis and seborrhoeic dermatitis have an inflammatory component in the disease process, the use of a CBD gel might be beneficial in treatment of the latter condition.[7] this combination reduces the occurrence of side-effects associated with betamethasone dipropionate alone.[5] This study aimed to investigate the off-label use of a CBD gel in the treatment of moderate-to-severe scalp seborrhoeic dermatitis
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