Abstract
BackgroundWe aim to analyze the risk factors for pneumothorax associated with computed tomography (CT)-guided percutaneous core needle biopsy (PCNB) of the lung. Whether the lung function characteristics are related to pneumothorax is unclear.MethodsWe retrospectively evaluated 343 patients who received CT-guided pulmonary PCNBs and underwent preoperative pulmonary function testing. Demographical, lesion-related, procedure-related features and histopathological diagnosis, as well as results of pulmonary function test were analyzed as risk factors of pneumothoraxResultsVariables associated with higher rate of pneumothorax were location of lesion, presence of emphysema, and dwell time. The proportion of middle lobe, lingular, or lower lobe lesions in pneumothorax group (30/50, 60.0%) is higher than non-pneumothorax group (113/293, 38.6%). The incidence of emphysema in pneumothorax group was significantly higher than that in non-pneumothorax group (34.0% vs. 7.5%). Obstructive pulmonary function abnormalities, not restrictive, mixed ventilation function abnormalities and small airway dysfunction, correlated with pneumothorax. Multivariate logistic regression analysis showed lower location of lesion sampled and presence of emphysema were independent predictors of pneumothorax. Although dwell time, FEV1/FVC ratio, FEF50%, FEF75% and FEF25–75% were significantly correlated with pneumothorax on univariate analysis, these were not confirmed to be independent predictors.ConclusionsPatients with obstructive pulmonary dysfunction have a higher risk of pneumothorax. Presence of emphysema was the most important predictor of pneumothorax, followed by location of lesion.
Highlights
Computed tomography (CT)-guided percutaneous core needle biopsy (PCNB) of the lung has been widely considered as a common and effective procedure, and has a high degree of accuracy in clinicopathologic diagnosis.Pooled overall complication rates for PCNB and fine needle aspiration biopsy (FNAB) from 32 articles (8133 procedures) were 38.8% and 24.0%, respectively [1]
Overall complication rate was higher for PCNB than FNAB, there is a tendency for PCNB to replace FNAB to provide a lower false-negative rate (< 10%) in the diagnosis of pulmonary diseases [2]
This study focused on the role of lung function in predicting the risk of pneumothorax caused by PCNB, as well as the common risk factors
Summary
Computed tomography (CT)-guided percutaneous core needle biopsy (PCNB) of the lung has been widely considered as a common and effective procedure, and has a high degree of accuracy in clinicopathologic diagnosis. Pooled overall complication rates for PCNB and fine needle aspiration biopsy (FNAB) from 32 articles (8133 procedures) were 38.8% (95% CI 34.3–43.5%) and 24.0% (95% CI 18.2–30.8%), respectively [1]. Overall complication rate was higher for PCNB than FNAB, there is a tendency for PCNB to replace FNAB to provide a lower false-negative rate (< 10%) in the diagnosis of pulmonary diseases [2]. The false-negative rate of FNAB is as high as 20% in the diagnosis of lung malignant tumors. We aim to analyze the risk factors for pneumothorax associated with computed tomography (CT)guided percutaneous core needle biopsy (PCNB) of the lung. Whether the lung function characteristics are related to pneumothorax is unclear
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
