The role of circadian rhythm in breast cancer, lung cancer, and colorectal cancer

Abstract

Circadian rhythm is a biological rhythm system with a self-regulating function and a 24-hour cycle that is synchronized with the alternation of day and night and is driven by circadian clock genes and clock-control genes. The circadian clock governs and controls processes like immune, metabolism, endocrine, cell division and proliferation, apoptosis, and sleep, allowing cells, tissues, and organs to carry out different living activities in an organized and coordinated way. The root cause of tumors is gene mutations that cause the body to lose its normal regulation of cell growth. According to studies, cancer and problems of biological rhythm are tightly linked. Related epidemiological studies are related to the occurrence and inhibition of tumors by circadian rhythms the molecular mechanism of action has become a hot issue. In this paper, combined with relevant research at home and abroad, we focus on the specific association between circadian rhythm and the high occurrence of breast cancer, lung cancer, and colorectal cancer in three populations, as well as the part circadian clocks play at the molecular level in tumor development and progression, and discuss the timing of cancer. Therapeutics is a novel therapeutic field that has the potential to increase efficacy and minimize negative effects. A sounder theoretical foundation for the identification, management, and prognosis of clinical cancers will be made possible by the clarification of the circadian clock in cancer.