Abstract
The crystal structure of AT-rich deoxynucleotides was retrieved from the Nucleic Acid Database and analyzed with the use of our program CHPI. It has been found that the thymidine 5-methyl group favorably interacts with an adenine ring in the same strand. Since an AT sequence is accompanied with another AT in the complementary strand, the interaction is duplicated, thus forming a twin CH/pi interaction. An AT step becomes stickier than other sequences by the above network. A number of CH/pi contacts have also been found in the crystal structure of A-tract. A successive N/T-methyl stacking in the same strand may contribute in making these steps robust and straight. The role of methyl groups in modified DNA has been discussed on a similar basis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
