Abstract
Objective: to study the association of genetic polymorphisms of chemokines (+1931А/Т ССL4, A/G CXCL11 (rs4512021), -403A/G CCL5, C/G CCL2 (rs2857657), -801G/A CXCL12) with arterial pressure in patients with chronic glomerulonephritis. Materials and methods: the study group comprised 700 people, including 238 patients with chronic glomerulonephritis and 462 controls. When assessing the level of blood pressure, the patients were divided into three groups: with arterial pressure less than 140/90 mm Hg - 84 patients, with arterial pressure from 140/90 to 159/100 mm Hg - 96 patients with arterial pressure more than 160/110 mm Hg - 52 patients. Th e material for the study was DNA samples isolated from whole venous blood by the phenolchloroform extraction method. Th e analysis of the studied polymorphisms was carried out by the method of detection of TaqMan probes by means of real-time PCR. Results: it was found that a high level of diastolic blood pressure in patients with chronic glomerulonephritis is associated with the molecular-genetic markers GG and CG CCL2 (rs2857657) (p=0,014), the risk factor for the development of severe arterial hypertension during the disease is the allele A CXCL11 (rs4512021) (p=0,04, OR=1,65). Conclusion: new data on the involvement of A/G CXCL11 (rs4512021) and C/G CCL2 (rs2857657) polymorphisms of chemokine genes in the development of arterial hypertension in patients with chronic glomerulonephritis of the Central Chernozem Region of Russia have been revealed.
Highlights
Цель: изучить ассоциации генетических полиморфизмов хемокинов (+1931А/Т ССL4, A/G CXCL11, -403A/G CCL5, C/G CCL2, -801G/A CXCL12) с показателями артериального давления у больных хроническим гломерулонефритом
When assessing the level of blood pressure, the patients were divided into three groups: with arterial pressure less than 140/90 mm Hg - 84 patients, with arterial pressure from 140/90 to 159/100 mm Hg - 96 patients with arterial pressure more than 160/110 mm Hg - 52 patients
Results: it was found that a high level of diastolic blood pressure in patients with chronic glomerulonephritis is associated with the molecular-genetic markers GG and CG CCL2 (p=0,014), the risk factor for the development of severe arterial hypertension during the disease is the allele A CXCL11 (p=0,04, OR=1,65)
Summary
Роль генов хемокинов в развитии артериальной гипертонии у больных хроническим гломерулонефритом. Цель: изучить ассоциации генетических полиморфизмов хемокинов (+1931А/Т ССL4, A/G CXCL11 (rs4512021), -403A/G CCL5, C/G CCL2 (rs2857657), -801G/A CXCL12) с показателями артериального давления у больных хроническим гломерулонефритом. Выводы: выявлены новые данные о вовлечённости полиморфизмов A/G CXCL11 (rs4512021) и C/G CCL2 (rs2857657) генов хемокинов в развитии артериальной гипертонии у больных хроническим гломерулонефритом Центрального Черноземья России. Objective: to study the association of genetic polymorphisms of chemokines (+1931А/Т ССL4, A/G CXCL11 (rs4512021), -403A/G CCL5, C/G CCL2 (rs2857657), -801G/A CXCL12) with arterial pressure in patients with chronic glomerulonephritis. Results: it was found that a high level of diastolic blood pressure in patients with chronic glomerulonephritis is associated with the molecular-genetic markers GG and CG CCL2 (rs2857657) (p=0,014), the risk factor for the development of severe arterial hypertension during the disease is the allele A CXCL11 (rs4512021) (p=0,04, OR=1,65). Conclusion: new data on the involvement of A/G CXCL11 (rs4512021) and C/G CCL2 (rs2857657) polymorphisms of chemokine genes in the development of arterial hypertension in patients with chronic glomerulonephritis of the Central Chernozem Region of Russia have been revealed
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