Abstract
The COVID-19 pandemic has become a serious challenge for the healthcare system and the economy of many states, and understanding the molecular mechanisms of the pathogenesis of this disease has become a significant challenge for modern science. At the same time, for the first time, a number of high-precision and high-throughput methods for analyzing molecular processes were available to scientists, including technologies for studying changes in chromatin at the genomic level. In this review, we discuss various modern methods that have been used or can be used to study changes in the structure and dynamics of chromatin during infection with SARS-CoV-2, present the results of currently available studies on the role of these changes in the pathogenesis of COVID-19, and in conclusion we review the currently known molecular mechanisms of chromatin modulation that occur during infection with SARS-CoV-2.
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