Abstract
Metabolomics is concerned with the comprehensive analysis of endogenous low-molecular-weight compounds in biological samples. Capillary electrophoresis-mass spectrometry (CE-MS) has demonstrated to be a powerful technique for the profiling of polar and charged metabolites in biological samples. In this chapter we describe the most recent developments in CE-MS for metabolomics, including both targeted and nontargeted approaches. This chapter covers the use of various CE separation modes, capillary coatings, CE-MS interfacing, sample pretreatment, and data analysis methods used in CE-MS for metabolomics. The applicability of CE-MS in metabolomics research is illustrated by examples of the analysis of various biological samples. Future considerations such as the use of sheathless CE-MS interfacing and challenges for large-scale and (quantitative) clinical metabolomics studies are discussed. CE-MS-based metabolomics studies reported between January 2006 and June 2011 and information on sample type and pretreatment and MS detection mode are summarized in tables.
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