Abstract
The histodifferentiation and migration of cells of the stratum intermedium in the enamel organ of the guinea pig molar was traced by using tritiated thymidine. These cells gave rise to the cells of the stellate reticulum and to the stratified squamous cell layer of the epithelial attachment around the neck of the erupting tooth. The latter tissue was capable of producing a keratin layer. Amorphous intercellular substance in the stellate reticulum disappeared before enamel matrix production began, but not until the preameloblasts ceased to divide.
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